chembioradical@inct.pl
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CHEMBIORAD Working Groups

General

Four working groups (WG1-WG4) address the formation, reactivity and fate of free radicals involving bio-molecules, such as unsaturated lipids, aromatic-, cyclic- and sulphur-containing amino acid residues, sugar and base moieties of nucleic acids.

WG1 – Lipid geometrical isomers - 9 members
WG Leader: Carla Ferreri, Italy; e-mail: cferreri@isof.cnr.it
Tasks: (i) Lipid libraries for identification of biomarkers of radical stress (link to pathologies and aging); (ii) Lipid isomerization or oxidation: modified lipids and signal pathways; (iii) Preventive systems for lipid damage.
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WG2 – Sulfur, aromatic and proline residues - 9 members
WG Leader: Chantal Houeè-Levin, France; e-mail: chantal.houee-levin@lcp.u-psud.fr
Tasks: (i) Peptide/protein libraries of modification at targeted residues: cysteine, methionine, proline and aromatics; (ii) Radical functioning of enzymes; (iii) Biological activity of modified sequences and link to diseases and aging; (iv) Preventive systems for protein damage.
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WG3 – Base and sugar radical reactivity in nucleic acids - 11 members
WG Leader: Thomas Carell, Germany; e-mail: Thomas.Carell@cup.uni-muenchen.de
Tasks: (i) Radical reactivity involving base and sugar units of nucleic acids (charge transfer, drug activity, radical stress); (ii) Repair and preventive systems for nucleic acid damage; (iii) Application to medicine and nanotechnology.
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WG4 – Biologically relevant small radicals - 18 members
WG Leader: Sara Goldstein, Israel; e-mail: sarag@vms.huji.ac.il
Tasks: (i) Small radical reactivity: link between chemical and biological studies; (ii) Specific reactions with lipids, proteins and nucleic acid units; (iii) Products characterization and use as biomarkers; (iv) Systems controlling the generation and reactivity of small radicals.
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